Single dose pharmacokinetic study of clobazam in normal volunteers and epileptic patients.

@article{Jawad1984SingleDP,
  title={Single dose pharmacokinetic study of clobazam in normal volunteers and epileptic patients.},
  author={Saeeda Jawad and Alan Richens and J R Oxley},
  journal={British journal of clinical pharmacology},
  year={1984},
  volume={18 6},
  pages={873-7}
}
The pharmacokinetics of clobazam were studied in six healthy volunteers and six age and sex matched enzyme-induced epileptic patients. In the epileptic patients the area under the plasma concentration-time curve for clobazam was significantly smaller and the area under the plasma concentration-time curve for N-desmethylclobazam was significantly greater than in the healthy volunteers. Plasma N-desmethylclobazam concentrations were found to be much higher than those of clobazam in the epileptic… CONTINUE READING