Single-dose ondansetron for the prevention of cisplatin-induced emesis: efficacy results.

@article{Hainsworth1992SingledoseOF,
  title={Single-dose ondansetron for the prevention of cisplatin-induced emesis: efficacy results.},
  author={John D Hainsworth and Paul Joseph Hesketh},
  journal={Seminars in oncology},
  year={1992},
  volume={19 6 Suppl 15},
  pages={14-9}
}
Ondansetron 0.15 mg/kg, given intravenously (IV) every 4 hours for three doses, has replaced metoclopramide as standard antiemetic therapy for patients receiving cisplatin-based chemotherapy. Several clinical observations suggested that ondansetron may be effective when given in a single dose: (1) demonstration of efficacy over a wide dose range, (2) similar efficacy with dosing intervals of 2, 4, 6, and 8 hours, and (3) efficacy of single-dose regimens with high-dose metoclopramide and other 5… CONTINUE READING

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