Single dose of MDMA causes extensive decrement of serotoninergic fibre density without blockage of the fast axonal transport in Dark Agouti rat brain and spinal cord

@article{Kovacs2007SingleDO,
  title={Single dose of MDMA causes extensive decrement of serotoninergic fibre density without blockage of the fast axonal transport in Dark Agouti rat brain and spinal cord},
  author={G. Kovacs and R. And{\'o} and C. {\'A}dori and E. Kirilly and A. Benedek and M. Palkovits and G. Bagdy},
  journal={Neuropathology and Applied Neurobiology},
  year={2007},
  volume={33}
}
Prolonged neurotoxicity of the recreational drug, MDMA (3,4‐methylenedioxymethamphetamine) on serotoninergic axon terminals has been suggested. The effect of a single (15 mg/kg) dose of intraperitoneally administered MDMA on serotoninergic fibre density, defined by tryptophan hydroxylase (TpH) and serotonin transporter (5‐HTT) immunoreactivity, has been evaluated in the spinal cord and brain areas in Dark Agouti rats, 7 and 180 days after MDMA applications. Immunostaining for amyloid precursor… Expand
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