Single dose disposition of chloroquine in kwashiorkor and normal children--evidence for decreased absorption in kwashiorkor.

@article{Walker1987SingleDD,
  title={Single dose disposition of chloroquine in kwashiorkor and normal children--evidence for decreased absorption in kwashiorkor.},
  author={Oladapo Walker and Adekunle H. Dawodu and Lateef A Salako and Gunnar Alv{\'a}n and Abiodun O. Johnson},
  journal={British journal of clinical pharmacology},
  year={1987},
  volume={23 4},
  pages={
          467-72
        }
}
The single dose disposition of chloroquine was studied in five children with kwashiorkor and six normal control children after an oral dose of 10 mg kg-1 of chloroquine base. Plasma concentrations of chloroquine and its main metabolite were assayed by high performance liquid chromatography (h.p.l.c.). Chloroquine was detectable for up to 21 days in all the subjects. Chloroquine was detectable in all the subjects within 30 min after giving the drug except in one subject. Peak levels were reached… CONTINUE READING

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