Single-dose ciraparantag safely and completely reverses anticoagulant effects of edoxaban.

@article{Ansell2017SingledoseCS,
  title={Single-dose ciraparantag safely and completely reverses anticoagulant effects of edoxaban.},
  author={Jack Ansell and Sasha H Bakhru and Bryan E Laulicht and Solomon S Steiner and Michael A. Grosso and Karen R. Brown and Victor Dishy and Hans J. Lanz and Michele F. Mercuri and Robert J Noveck and James C Costin},
  journal={Thrombosis and haemostasis},
  year={2017},
  volume={117 2},
  pages={238-245}
}
Of the new direct oral anticoagulants, direct factor Xa inhibitors are limited by the absence of a proven reversal agent. We assessed the safety, tolerability and impact on anticoagulation reversal of ciraparantag (PER977) alone and following a 60 mg dose of the FXa inhibitor edoxaban. Escalating, single IV doses of ciraparantag were administered alone and following a 60 mg oral dose of edoxaban in a double-blind, placebo-controlled fashion to healthy subjects. Serial assessments of the… CONTINUE READING
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