Single-dose azithromycin versus benzathine benzylpenicillin for treatment of yaws in children in Papua New Guinea: an open-label, non-inferiority, randomised trial

@article{Mitj2012SingledoseAV,
  title={Single-dose azithromycin versus benzathine benzylpenicillin for treatment of yaws in children in Papua New Guinea: an open-label, non-inferiority, randomised trial},
  author={Oriol Mitj{\`a} and Russell Hays and Anthony Ipai and Moses Penias and Raymond Paru and David Fagaho and Elisa Lazzari and Quique Bassat},
  journal={The Lancet},
  year={2012},
  volume={379},
  pages={342-347}
}

Figures and Tables from this paper

A Single Dose Oral Azithromycin versus Intramuscular Benzathine Penicillin for the Treatment of Yaws-A Randomized Non Inferiority Trial in Ghana
TLDR
A single oral dose of azithromycin, at a dosage of 30mg/kg, was non-inferior to a single dose of intramuscular benzathine penicillin for the treatment of early yaws among Ghanaian patients, and provides additional support for the WHO policy for use of oral azithromecin for the eradication of yaws in resource-poor settings.
Mass treatment with single-dose azithromycin for yaws.
TLDR
The prevalence of active and latent yaws infection fell rapidly and substantially 12 months after high-coverage mass treatment with azithromycin, with the reduction perhaps aided by subsequent activities to identify and treat new cases of yaws.
A Trial of Three Rounds of Mass Drug Administration with Azithromycin for Yaws
TLDR
An open-label cluster-randomized community trial in a yaws-endemic area of Papua New Guinea shows that three rounds of azithromycin MDA 6 months apart are better than one round of azyridine MDA with two rounds of targeted treatment for decreasing the community prevalence of yaws.
Single-dose azithromycin to treat latent yaws.
Prevalence of Active and Latent Yaws in the Solomon Islands 18 Months after Azithromycin Mass Drug Administration for Trachoma
TLDR
The benefit of a single round of mass treatment with azithromycin 20mg/kg appears to extend to 18 months without any further intervention, and the lack of a significant change in seroprevalence from 6 to18 months after mass treatment might suggest that interventions could be spaced at yearly intervals without a significant loss of impact.
Community-based mass treatment with azithromycin for the elimination of yaws in Ghana—Results of a pilot study
TLDR
A single round of high coverage TCT with azithromycin in a yaws affected sub-district adjoining other endemic areas is effective in reducing the prevalence of seropositive children and the prevalenceof early skin lesions consistent with yaws one year following the intervention.
Randomized Trial of Community Treatment With Azithromycin and Ivermectin Mass Drug Administration for Control of Scabies and Impetigo
  • M. Marks, Hilary Toloka, A. Steer
  • Medicine, Biology
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 2019
TLDR
Co-administration of azithromycin with ivermectin led to similar decreases in scabies and impetigo prevalence compared to iver MDA alone, and there was a transient increase in the proportion of macrolide-resistant S. aureus strains following azidromycin MDA.
...
...

References

SHOWING 1-10 OF 30 REFERENCES
Single-dose azithromycin versus penicillin G benzathine for the treatment of early syphilis.
TLDR
Single-dose oral azithromycin is effective in treating syphilis and may be particularly useful in developing countries in which the use of penicillin G benzathine injections is problematic, however, recent reports of azitromycin-resistant Treponema pallidum in the United States indicate the importance of continued monitoring for resistance.
A phase III equivalence trial of azithromycin versus benzathine penicillin for treatment of early syphilis.
TLDR
The efficacy of azithromycin at a dosage of 2.0 g administered orally was equivalent to that of benzathine penicillin G for the treatment of early syphilis in persons without HIV infection.
Comparison of azithromycin and ceftriaxone for the treatment of chancroid.
TLDR
It is concluded that a single 1-g oral dose of azithromycin is as effective as a 250-mg im dose of ceftriaxone for the treatment of chancroid.
Failure of penicillin treatment of yaws on Karkar Island, Papua New Guinea.
TLDR
Treatment failure was most likely to have been due to reduced susceptibility to penicillin of Treponema pallidum subsp.
Efficacy of a targeted, oral penicillin-based yaws control program among children living in rural South America.
TLDR
A targeted, oral penicillin-based treatment regimen can successfully treat dermatologic yAWs in individual children and can decrease the prevalence of skin yaws in a community in which it is endemic.
Global Challenge of Antibiotic-Resistant Treponema pallidum
  • L. Stamm
  • Medicine, Biology
    Antimicrobial Agents and Chemotherapy
  • 2009
TLDR
The genetic basis of T. pallidum macrolide resistance and the potential of this spirochete to develop additional antibiotic resistance that could seriously compromise syphilis treatment and control are discussed.
Efficacy of Single-Dose Azithromycin in Treatment of Acute Otitis Media in Children after a Baseline Tympanocentesis
TLDR
Children with acute otitis media underwent tympanocentesis and were given a single dose of 30 mg of azithromycin/kg of body weight and clinical cure rates were consistent with historical rates for the 5-day dosing regimen.
A Point Mutation Associated with Bacterial Macrolide Resistance Is Present in Both 23S rRNA Genes of an Erythromycin-ResistantTreponema pallidum Clinical Isolate
TLDR
Macrolide resistance usually results from target site alteration due to methylation or mutations in the peptidyltransferase region of 23S rRNA in bacteria that contain one or two copies of these genes, and this observation prompted us to analyze the corresponding regions of the two23S r RNA genes of T. pallidum Nichols strain.
The control of endemic treponematoses.
TLDR
One important factor has been the failure of many countries to integrate active control measures into local health services after the mass campaigns and incidence of yaws and endemic syphilis have returned to high levels.
Evaluation of azithromycin resistance in Treponema pallidum specimens from Madagascar.
TLDR
No evidence of resistance to azithromycin is found in specimens from 141 patients with syphilitic lesions in Madagascar suggesting resistance is geographically isolated and supporting use of azithroitin as alternative treatment for early syphilis in Madagascar.
...
...