Single-dose azithromycin versus benzathine benzylpenicillin for treatment of yaws in children in Papua New Guinea: an open-label, non-inferiority, randomised trial

@article{Mitj2012SingledoseAV,
  title={Single-dose azithromycin versus benzathine benzylpenicillin for treatment of yaws in children in Papua New Guinea: an open-label, non-inferiority, randomised trial},
  author={O. Mitj{\`a} and Russell Hays and Anthony Ipai and Moses Penias and Q. Bassat},
  journal={The Lancet},
  year={2012},
  volume={379},
  pages={342-347}
}
BACKGROUND Yaws--an endemic treponematosis and, as such, a neglected tropical disease--is re-emerging in children in rural, tropical areas. Oral azithromycin is effective for syphilis. We assessed the efficacy of azithromycin compared with intramuscular long-acting penicillin to treat patients with yaws. METHODS We did an open-label, non-inferiority, randomised trial at Lihir Medical Centre, Papua New Guinea, between Sept 1, 2010, and Feb 1, 2011. Children aged 6 months to 15 years with a… Expand
113 Citations

Paper Mentions

Interventional Clinical Trial
Yaws, an endemic treponematosis and as such a neglected tropical disease (NTD), is currently making a comeback in children in rural areas. Injectable long acting penicillin remains the… Expand
ConditionsNeglected Tropical Disease, Treponema Infection, Yaws
InterventionDrug
Mass treatment with single-dose azithromycin for yaws.
  • 71
  • PDF
Single-dose azithromycin to treat latent yaws.
  • PDF
Prevalence of Active and Latent Yaws in the Solomon Islands 18 Months after Azithromycin Mass Drug Administration for Trachoma
  • 17
  • PDF
Randomized Trial of Community Treatment With Azithromycin and Ivermectin Mass Drug Administration for Control of Scabies and Impetigo
  • M. Marks, Hilary Toloka, +13 authors A. Steer
  • Medicine
  • Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 2019
  • 25
  • PDF
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 31 REFERENCES
Single-dose azithromycin versus penicillin G benzathine for the treatment of early syphilis.
  • 233
  • PDF
A phase III equivalence trial of azithromycin versus benzathine penicillin for treatment of early syphilis.
  • 94
  • PDF
Comparison of azithromycin and ceftriaxone for the treatment of chancroid.
  • 42
Failure of penicillin treatment of yaws on Karkar Island, Papua New Guinea.
  • 40
Efficacy of a targeted, oral penicillin-based yaws control program among children living in rural South America.
  • 37
  • PDF
Global Challenge of Antibiotic-Resistant Treponema pallidum
  • L. Stamm
  • Medicine, Biology
  • Antimicrobial Agents and Chemotherapy
  • 2009
  • 139
  • PDF
...
1
2
3
4
...