Single dose and multiple dose pharmacokinetics of 2′-fluoro-2′,3′-dideoxyadenosine and 2′-fluoro-2′,3′-dideoxyinosine, anti-HIV agents, in rats

@article{Srinivas2010SingleDA,
  title={Single dose and multiple dose pharmacokinetics of 2′-fluoro-2′,3′-dideoxyadenosine and 2′-fluoro-2′,3′-dideoxyinosine, anti-HIV agents, in rats},
  author={N. Srinivas and W. Shyu},
  journal={European Journal of Drug Metabolism and Pharmacokinetics},
  year={2010},
  volume={24},
  pages={329-334}
}
  • N. Srinivas, W. Shyu
  • Published 2010
  • Medicine
  • European Journal of Drug Metabolism and Pharmacokinetics
SummaryA single and multiple dose pharmacokinetic (PK) study was conducted in rats following oral administration of 2′-fluoro-2′,3′-dideoxyadenosine (FddA) and 2′-fluoro-2′,3′-dideoxyinosine (FddI) at three dose levels. Six rats/gender were assigned to one of the three FddA or FddI dose levels: 40, 250, and 1000 mg/kg/day. Three rats/gender were assigned to the PK study on day 1, while the remaining 3 rats/gender were assigned to the PK study on day 14. The rats received the appropriate doses… Expand

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