Single-dose actinomycin D in the treatment of postmolar trophoblastic disease.

@article{Schlaerth1984SingledoseAD,
  title={Single-dose actinomycin D in the treatment of postmolar trophoblastic disease.},
  author={John B Schlaerth and Colette Morrow and R H Nalick and O Gaddis},
  journal={Gynecologic oncology},
  year={1984},
  volume={19 1},
  pages={53-6}
}
From 1973 to 1982 single-dose (0.04 mg/kg or 1.25 mg/m2), biweekly actinomycin D was used to treat 28 women with postmolar, good-prognosis trophoblastic disease. Among the 17 patients fully evaluable for response to treatment 12 were nonmetastatic (NMTD) and 5 had lung metastases (MTD). Nine NMTD patients and 5 MTD patients achieved titer remission for an overall cure rate of 82.5%. Three patients were lost to follow-up with elevated serum human chorionic gonadotropin titers. The average number… CONTINUE READING
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