Single dosage of doxycycline for prophylaxis against leptospiral infection and leptospirosis during urban flooding in southern Thailand: a non-randomized controlled trial.

@article{Chusri2014SingleDO,
  title={Single dosage of doxycycline for prophylaxis against leptospiral infection and leptospirosis during urban flooding in southern Thailand: a non-randomized controlled trial.},
  author={Sarunyou Chusri and Edward B McNeil and Thanaporn Hortiwakul and Boonsri Charernmak and Somporn Sritrairatchai and Wichai Santimaleeworagun and Sutthiporn Pattharachayakul and Paritasana Suksanan and Butsaya K Thaisomboonsuk and Richard G Jarman},
  journal={Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy},
  year={2014},
  volume={20 11},
  pages={709-15}
}
This study was conducted to investigate the protective efficacy of a single dosage of 200 mg doxycycline against leptospiral infection and leptospirosis and associated risk factors among residents exposed to flooding in southern Thailand. Of 641 participants, 600 received doxycycline while 41 did not. Twenty two participants were infected with Leptospira and six developed leptospirosis. Having a laceration wound was significantly associated with leptospiral infection (odds ratio [OR] = 37.20; P… CONTINUE READING

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