Single-donor, marginal-dose islet transplantation in patients with type 1 diabetes.

  title={Single-donor, marginal-dose islet transplantation in patients with type 1 diabetes.},
  author={Bernhard J. Hering and Raja Kandaswamy and Jeffrey D Ansite and Peter M. Eckman and Masahiko Nakano and Toshiya Sawada and Ippei Matsumoto and S Ihm and Hui-jian Zhang and Jamen Parkey and David J. Hunter and David E. R. Sutherland},
  volume={293 7},
CONTEXT Islet allografts from 2 to 4 donors can reverse type 1 diabetes. However, for islet transplants to become a widespread clinical reality, diabetes reversal must be achieved with a single donor to reduce risks and costs and increase the availability of transplantation. OBJECTIVE To assess the safety of a single-donor, marginal-dose islet transplant protocol using potent induction immunotherapy and less diabetogenic maintenance immunosuppression in recipients with type 1 diabetes. A… CONTINUE READING
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