Single domain intrabodies against WASP inhibit TCR-induced immune responses in a transgenic mouse model

@inproceedings{Sato2014SingleDI,
  title={Single domain intrabodies against WASP inhibit TCR-induced immune responses in a transgenic mouse model},
  author={Mitsuru Sato and Chisato Sakuma and Takato Takenouchi and Hiroshi Kitani},
  year={2014}
}
Background Gene-knockout and RNA interference (RNAi) technologies are powerful tools for understanding gene function. However, these gene-knockout and silencing techniques cannot be used to analyze domain structures, functions, and post-translationally modified protein functions. Intracellularly expressed antibody fragments (intrabodies) have been used as powerful tools for clinical applications and for basic studies of intracellular proteins. Specific binding of intrabodies to the target… CONTINUE READING
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