Single-cytokine-producing CD4 memory cells predominate in type 1 and type 2 immunity.

@article{Karulin2000SinglecytokineproducingCM,
  title={Single-cytokine-producing CD4 memory cells predominate in type 1 and type 2 immunity.},
  author={Alexey Y. Karulin and Maike D. Hesse and Magdalena Tary-Lehmann and Paul Viktor Lehmann},
  journal={Journal of immunology},
  year={2000},
  volume={164 4},
  pages={1862-72}
}
The patterns of Ag-induced cytokine coexpression in normal, in vivo-primed CD4 memory T cells has remained controversial because the low frequency at which these cells occur has effectively prevented direct ex vivo measurements. We have overcome this limitation by using two-color cytokine enzyme-linked immunospot assays and computer-assisted image analysis. We found CD4 memory cells that simultaneously expressed IL-2, IL-3, IL-4, IL-5, and IFN-gamma to be rare (0-10%). This cytokine segregation… CONTINUE READING

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