Single cysteine to tyrosine transition inactivates the growth inhibitory function of Piedmontese myostatin.

@article{Berry2002SingleCT,
  title={Single cysteine to tyrosine transition inactivates the growth inhibitory function of Piedmontese myostatin.},
  author={Carole J Berry and Mark F. Thomas and Brett Langley and Mridula Sharma and Ravi Kambadur},
  journal={American journal of physiology. Cell physiology},
  year={2002},
  volume={283 1},
  pages={C135-41}
}
Myostatin, a member of the transforming growth factor-beta superfamily, is a secreted growth factor that is proteolytically processed to give COOH-terminal mature myostatin and NH2-terminal latency-associated peptide in myoblasts. Piedmontese cattle are a heavy-muscled breed that express a mutated form of myostatin in which cysteine (313) is substituted with tyrosine. Here we have characterized the biology of this mutated Piedmontese myostatin. Northern and Western analyses indicate that there… CONTINUE READING

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