Single circulating tumor cell detection and overall survival in nonmetastatic breast cancer.

@article{Bidard2010SingleCT,
  title={Single circulating tumor cell detection and overall survival in nonmetastatic breast cancer.},
  author={François-Cl{\'e}ment Bidard and Claire Mathiot and Suzette Delaloge and Etienne G C Brain and Sylvie Giachetti and P de Cremoux and Michel M. Marty and J. Y. Pierga},
  journal={Annals of oncology : official journal of the European Society for Medical Oncology},
  year={2010},
  volume={21 4},
  pages={729-33}
}
BACKGROUND Circulation of cancer cells in the blood is a mandatory step for metastasis, but circulating tumor cells (CTC) have a low metastatic efficiency in preclinical animal models. In this prospective study, we reported the clinical outcome of nonmetastatic breast cancer patients according to CTC detection. PATIENTS AND METHODS In 115 nonmetastatic patients diagnosed with large operable or locally advanced breast cancer, we prospectively detected CTC using the CellSearch system before and… CONTINUE READING

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