Single chromosome transcriptional profiling reveals chromosome-level regulation of gene expression

@inproceedings{Levesque2013SingleCT,
  title={Single chromosome transcriptional profiling reveals chromosome-level regulation of gene expression},
  author={Marshall J. Levesque and Arjun Raj},
  booktitle={Nature Methods},
  year={2013}
}
We report intron chromosomal expression FISH (iceFISH), a multiplex imaging method for measuring gene expression and chromosome structure simultaneously on single chromosomes. We find substantial differences in transcriptional frequency between genes on a translocated chromosome and the same genes in their normal chromosomal context in the same cell. Correlations between genes on a single chromosome pointed toward a cis chromosome-level transcriptional interaction spanning 14.3 megabases. 
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