Single-channel recording of a store-operated Ca2+ channel in Jurkat T lymphocytes.

  title={Single-channel recording of a store-operated Ca2+ channel in Jurkat T lymphocytes.},
  author={Hubert H. Kerschbaum and Michael D Cahalan},
  volume={283 5403},
In T lymphocytes, a store-operated calcium ion (Ca2+) entry mechanism termed the calcium release-activated Ca2+ channel (CRAC channel) underlies the sustained or oscillatory intracellular calcium concentration signal required for interleukin-2 gene expression and cell proliferation. The use of sodium ions as a current carrier enabled single-channel recordings of CRAC channels during activation, inactivation, and blockade of current in the presence of divalent cations. A large conductance of 36… CONTINUE READING

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