Single-channel currents recorded from membrane of denervated frog muscle fibres

@article{Neher1976SinglechannelCR,
  title={Single-channel currents recorded from membrane of denervated frog muscle fibres},
  author={Erwin Neher and Bert J. Sakmann},
  journal={Nature},
  year={1976},
  volume={260},
  pages={799-802}
}
THE ionic channel associated with the acetylcholine (ACh) receptor at the neuromuscular junction of skeletal muscle fibres is probably the best described channel in biological membranes. Nevertheless, the properties of individual channels are still unknown, as previous studies were concerned with average population properties. Macroscopic conductance fluctuations occurring in the presence of ACh were analysed to provide estimates for single channel conductance and mean open times1–3. The values… Expand
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