Single-channel currents activated by low intracellular pH in cultured hippocampal neurons of rat.


Patch clamp technique was applied to the plasma membrane of cultured hippocampal neurons of rat. Elementary currents of a cation-selective channel were elicited by low intracellular pH (pHi 3.5-4.5). Channel activity starts with 1-2 min delay from the application of low pHi, and persists upon restoration of physiological pH conditions. The channel has a… (More)


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