Single-channel analyses of ethanol modulation of neuronal nicotinic acetylcholine receptors.

@article{Zuo2004SinglechannelAO,
  title={Single-channel analyses of ethanol modulation of neuronal nicotinic acetylcholine receptors.},
  author={Yi Zuo and Keiichi Nagata and Jay Z. Yeh and Toshio Narahashi},
  journal={Alcoholism, clinical and experimental research},
  year={2004},
  volume={28 5},
  pages={
          688-96
        }
}
BACKGROUND We have previously reported that ethanol potentiates the acetylcholine-induced currents of the alpha4beta2 neuronal nicotinic acetylcholine receptors in rat cortical neurons and of those that are stably expressed in human embryonic kidney cells. The potentiation of the maximal currents evoked by high concentrations of acetylcholine suggests that ethanol affects the channel gating. METHODS We performed single-channel patch-clamp experiments to elucidate the detailed mechanism of… CONTINUE READING

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