Single-chain factor XII exhibits activity when complexed to polyphosphate.

@article{Engel2014SinglechainFX,
  title={Single-chain factor XII exhibits activity when complexed to polyphosphate.},
  author={Rita Engel and Chelsea Marie Brain and Jonathan R Paget and Ausra S. Lionikiene and Nicola J Mutch},
  journal={Journal of thrombosis and haemostasis : JTH},
  year={2014},
  volume={12 9},
  pages={
          1513-22
        }
}
BACKGROUND The mechanism underpinning factor XII autoactivation was originally characterized with non-physiological surfaces, such as dextran sulfate (DS), ellagic acid, and kaolin. Several 'natural' anionic activating surfaces, such as platelet polyphosphate (polyP), have now been identified. OBJECTIVE To analyze the autoactivation of FXII by polyP of a similar length to that found in platelets (polyP70 ). METHODS AND RESULTS PolyP70 showed similar efficacy to DS in stimulating… CONTINUE READING
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Contact ignition by single-chain XIIa.

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