Single chain Ig/gamma gene-redirected human T lymphocytes produce cytokines, specifically lyse tumor cells, and recycle lytic capacity.

@article{Weijtens1996SingleCI,
  title={Single chain Ig/gamma gene-redirected human T lymphocytes produce cytokines, specifically lyse tumor cells, and recycle lytic capacity.},
  author={Mo E. M. Weijtens and Ralph A. Willemsen and Dinko Valerio and Kees J Stam and Reinder L. H. Bolhuis},
  journal={Journal of immunology},
  year={1996},
  volume={157 2},
  pages={836-43}
}
To enable construction of CTL with known predefined Ab specificity for adoptive immunotherapy, we constructed a chimeric scFv/gamma gene composed of the variable regions of a mAb joined to the Fc(epsilon)RI signaling receptor gamma-chain of mast cells. Introduction of this chimeric receptor into CTL rendered these lymphocytes specific for renal cell carcinoma. This approach combines the specificity of tumor-selective Abs with the efficacy of CTL to destroy tumor cells. We not only demonstrated… CONTINUE READING
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