Single-chain HLA-A2 MHC trimers that incorporate an immundominant peptide elicit protective T cell immunity against lethal West Nile virus infection.

@article{Kim2010SinglechainHM,
  title={Single-chain HLA-A2 MHC trimers that incorporate an immundominant peptide elicit protective T cell immunity against lethal West Nile virus infection.},
  author={Sojung Kim and Lijin Li and Curtis McMurtrey and William H. Hildebrand and Jon Weidanz and William E. Gillanders and Michael S Diamond and Ted H. Hansen},
  journal={Journal of immunology},
  year={2010},
  volume={184 8},
  pages={4423-30}
}
The generation of a robust CD8(+) T cell response is an ongoing challenge for the development of DNA vaccines. One problem encountered with classical DNA plasmid immunization is that peptides produced are noncovalently and transiently associated with MHC class I molecules and thus may not durably stimulate CD8(+) T cell responses. To address this and enhance the expression and presentation of the antigenic peptide/MHC complexes, we generated single-chain trimers (SCTs) composed of a single… CONTINUE READING
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