Corpus ID: 34604238

Single-chain Fv-streptavidin substantially improved therapeutic index in multistep targeting directed at disialoganglioside GD2.

@article{Cheung2004SinglechainFS,
  title={Single-chain Fv-streptavidin substantially improved therapeutic index in multistep targeting directed at disialoganglioside GD2.},
  author={N. Cheung and S. Modak and Yukang Lin and Hongfen Guo and P. Zanzonico and John Y Chung and Y. Zuo and J. Sanderson and S. Wilbert and L. Theodore and D. Axworthy and S. Larson},
  journal={Journal of nuclear medicine : official publication, Society of Nuclear Medicine},
  year={2004},
  volume={45 5},
  pages={
          867-77
        }
}
  • N. Cheung, S. Modak, +9 authors S. Larson
  • Published 2004
  • Chemistry, Medicine
  • Journal of nuclear medicine : official publication, Society of Nuclear Medicine
UNLABELLED Multistep targeting can improve the therapeutic index of antibody-based targeting, particularly relevant to pediatric tumors where acute toxicity and late effects of treatment are major concerns. Neuroblastoma is uniquely suited for such investigations because of its abundance of surface ganglioside GD2. METHODS 5F11scFv (scFv = single-chain variable fragment) was constructed from the variable regions of the heavy (V(H)) and kappa-light (V(L)) chain complementary DNA (cDNA) of anti… Expand
Reducing Epitope Spread during Affinity Maturation of an Anti-Ganglioside GD2 Antibody1
Pretargeted radioimmunotherapy with a single-chain antibody/streptavidin construct and radiolabeled DOTA-biotin: strategies for reduction of the renal dose.
Intraperitoneal Pretarget Radioimmunotherapy with CC49 Fusion Protein
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 41 REFERENCES
A tetravalent single-chain antibody-streptavidin fusion protein for pretargeted lymphoma therapy.
Antibody phage libraries for the next generation of tumor targeting radioimmunotherapeutics.
  • S. Denardo, G. Denardo, +5 authors P. Carter
  • Biology, Medicine
  • Clinical cancer research : an official journal of the American Association for Cancer Research
  • 1999
Targeting of ganglioside GD2 monoclonal antibody to neuroblastoma.
Clinical optimization of pretargeted radioimmunotherapy with antibody-streptavidin conjugate and 90Y-DOTA-biotin.
  • H. Breitz, P. Weiden, +6 authors J. Reno
  • Chemistry, Medicine
  • Journal of nuclear medicine : official publication, Society of Nuclear Medicine
  • 2000
Cure of human carcinoma xenografts by a single dose of pretargeted yttrium-90 with negligible toxicity.
Anti-idiotypic antibody as the surrogate antigen for cloning scFv and its fusion proteins.
...
1
2
3
4
5
...