Single-cell variation leads to population invariance in NF-κB signaling dynamics

Abstract

The activation dynamics of nuclear factor (NF)-κB have been shown to affect downstream gene expression. On activation, NF-κB shuttles back and forth across the nuclear envelope. Many dynamic features of this shuttling have been characterized, and most features vary significantly with respect to ligand type and concentration. Here, we report an invariant… (More)
DOI: 10.1091/mbc.E14-08-1267

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