Single-cell transcriptomes reveal characteristic features of human pancreatic islet cell types.

@article{Li2016SinglecellTR,
  title={Single-cell transcriptomes reveal characteristic features of human pancreatic islet cell types.},
  author={Jin Li and Johanna Klughammer and Matthias Farlik and Thomas Penz and Andreas Spittler and Charlotte Barbieux and Ekaterine Berishvili and Christoph Bock and Stefan Kubicek},
  journal={EMBO reports},
  year={2016},
  volume={17 2},
  pages={178-87}
}
Pancreatic islets of Langerhans contain several specialized endocrine cell types, which are commonly identified by the expression of single marker genes. However, the established marker genes cannot capture the complete spectrum of cellular heterogeneity in human pancreatic islets, and existing bulk transcriptome datasets provide averages across several cell populations. To dissect the cellular composition of the human pancreatic islet and to establish transcriptomes for all major cell types… CONTINUE READING

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