Single cell studies of the primate putamen

@article{Crutcher2004SingleCS,
  title={Single cell studies of the primate putamen},
  author={M. D. Crutcher and Mahlon R. Delong},
  journal={Experimental Brain Research},
  year={2004},
  volume={53},
  pages={244-258}
}
SummaryThe major goal of this study was to determine whether the activity of single cells in the primate putamen was better related to the direction of limb movement or to the underlying pattern of muscular activity. In addition, the neural responses to load application were studied in order to determine whether the same neurons were also responsive to somatosensory stimuli. Two rhesus monkeys were trained to perform a visuomotor arm tracking task which required elbow flexion/extension… Expand
Single cell studies of the primate putamen
TLDR
Clusters of neurons with similar functional properties may correspond to the subunits of the striatum which have been revealed by anatomic and morphologic studies and are proposed to represent the basic functional units of the Striatum in a manner analogous to the functional columns of the neocortex. Expand
The primate globus pallidus: neuronal activity related to direction of movement
TLDR
The major finding of the present study is that, as in the putamen, the activity of almost half of the neurons in GPe and GPi was related to the direction of movement, and similar proportions of cells in GP and putamen were related to static loads. Expand
Selective neuronal discharge in monkey putamen reflects intended direction of planned limb movements
TLDR
Two principal forms of task-related activity were observed among the 232 putamen neurons (all located within the region of arm representation) whose discharge patterns showed significant relations to one or more features of the behavioral paradigm. Expand
Role of primate basal ganglia and frontal cortex in the internal generation of movements
TLDR
The data show that single neurons in caudate and putamen were activated up to a few seconds before self-initiated movements that were performed, within the constraints of the experimental situation, with a considerable degree of temporal choice due to the absence of explicit external instructive or imperative stimuli. Expand
Activity in monkey substantia nigra neurons related to a simple learned movement
TLDR
The SN seems to play an important role in the control of specific motor mechanisms, probably modulating movement velocity, amplitude and direction, with little participation of somatosensory feedback. Expand
Modulation of neuronal activity in the monkey putamen associated with changes in the habitual order of sequential movements.
TLDR
It is suggested that task-related changes in activity of projection neurons may be an important factor contributing to the production and adjustment of sequential behavior executed in an automatic fashion, whereas putative interneurons may provide a signal for performance monitoring in specific contexts. Expand
Activity of primate putamen neurons is selective to the mode of voluntary movement: visually guided, self-initiated or memory-guided
TLDR
Results are consistent with the hypothesis that there are heterogeneous groups of neurons in the putamen, and that each group of neurons participates in retrieving a different kind of information required for movement based on either external sensory events or on internally stored information. Expand
Role of primate basal ganglia and frontal cortex in the internal generation of movements
TLDR
A considerably segregated population of striatal neurons engaged in the internal generation of movements is demonstrated, whereas processes underlying the execution of movements appear to involve overlapping neuronal populations. Expand
Single-unit activity in the globus pallidus and neostriatum of the rat during performance of a trained head movement
TLDR
The proportion of task-related neurons that exhibited responses with both movement-related and cue-related components was greater than has generally been reported in studies of cats and primates, suggesting that neurons with these response properties may be more predominant in the rat basal ganglia. Expand
The role of putamen and pallidum in motor initiation in the cat
TLDR
The fact that, for certain neurons, the changes of activity prior to movement were different in reaction time condition and in delayed condition showed that the pattern of activity preceding movement might depend on the temporal requirements for motor initiation. Expand
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References

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Single cell studies of the primate putamen
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Clusters of neurons with similar functional properties may correspond to the subunits of the striatum which have been revealed by anatomic and morphologic studies and are proposed to represent the basic functional units of the Striatum in a manner analogous to the functional columns of the neocortex. Expand
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