Single-cell sequencing provides clues about the host interactions of segmented filamentous bacteria (SFB).

@article{Pamp2012SinglecellSP,
  title={Single-cell sequencing provides clues about the host interactions of segmented filamentous bacteria (SFB).},
  author={S. J. Pamp and E. Harrington and S. Quake and D. Relman and P. Blainey},
  journal={Genome research},
  year={2012},
  volume={22 6},
  pages={
          1107-19
        }
}
Segmented filamentous bacteria (SFB) are host-specific intestinal symbionts that comprise a distinct clade within the Clostridiaceae, designated Candidatus Arthromitus. SFB display a unique life cycle within the host, involving differentiation into multiple cell types. The latter include filaments that attach intimately to intestinal epithelial cells, and from which "holdfasts" and spores develop. SFB induce a multifaceted immune response, leading to host protection from intestinal pathogens… Expand
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Comparative analysis with clostridial genomes suggested possible mechanisms for host responses and specific adaptations in the intestine, and SFB genomes encode typical genes for anaerobic fermentation and spore and flagella formation, but lack most of the amino acid biosynthesis enzymes. Expand
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Comparison of 16S rRNA sequences of segmented filamentous bacteria isolated from mice, rats, and chickens and proposal of "Candidatus Arthromitus".
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