Single cell mechanics of rat cardiomyocytes under isometric, unloaded, and physiologically loaded conditions.

@article{Nishimura2004SingleCM,
  title={Single cell mechanics of rat cardiomyocytes under isometric, unloaded, and physiologically loaded conditions.},
  author={Satoshi Kitakyushu-shi Nishimura and So-ichiro Yasuda and Masayoshi Katoh and Kelly P Yamada and Hiroshi Yamashita and Yasutake Saeki and Kenji Sunagawa and Ryozo Nagai and Toshiaki Hisada and Seiryo Sugiura},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2004},
  volume={287 1},
  pages={
          H196-202
        }
}
One of the most salient characteristics of the heart is its ability to adjust work output to external load. To examine whether a single cardiomyocyte preparation retains this property, we measured the contractile function of a single rat cardiomyocyte under a wide range of loading conditions using a force-length measurement system implemented with adaptive control. A pair of carbon fibers was used to clamp the cardiomyocyte, attached to each end under a microscope. One fiber was stiff, serving… CONTINUE READING

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VIEW 4 EXCERPTS
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  • 2007
VIEW 3 EXCERPTS
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References

Publications referenced by this paper.
SHOWING 1-10 OF 27 REFERENCES

A novel method to study contraction characteristics of a single cardiac myocyte using carbon fibers.

  • American journal of physiology. Heart and circulatory physiology
  • 2001
VIEW 7 EXCERPTS

Restoration of contractile function in isolated cardiomyocytes from failing human hearts by gene transfer of SERCA2a

F Del Monte, SE Harding, +6 authors RJ. Hajjar
  • Circulation 100: 2308–2311,
  • 1999
VIEW 1 EXCERPT