Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19

@article{Liao2020SinglecellLO,
  title={Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19},
  author={Mingfeng Liao and Yang Liu and Jing Yuan and Yanling Wen and Gang Xu and Juanjuan Zhao and Lin Cheng and Jin-xiu Li and Xin Wang and Fuxiang Wang and Lei Liu and Ido Amit and Shuye Zhang and Zheng Zhang},
  journal={Nature Medicine},
  year={2020},
  volume={26},
  pages={842-844}
}
Respiratory immune characteristics associated with Coronavirus Disease 2019 (COVID-19) severity are currently unclear. We characterized bronchoalveolar lavage fluid immune cells from patients with varying severity of COVID-19 and from healthy people by using single-cell RNA sequencing. Proinflammatory monocyte-derived macrophages were abundant in the bronchoalveolar lavage fluid from patients with severe COVID-9. Moderate cases were characterized by the presence of highly clonally expanded CD8… 
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