Single cell immune profiling by mass cytometry of newly diagnosed chronic phase chronic myeloid leukemia treated with nilotinib

@inproceedings{Gullaksen2017SingleCI,
  title={Single cell immune profiling by mass cytometry of newly diagnosed chronic phase chronic myeloid leukemia treated with nilotinib},
  author={Stein-Erik Gullaksen and J\orn Skavland and Sonia Gavasso and Vinko Tosevski and Krzysztof Warzocha and Claudia Dumrese and Augustin Ferrant and Tobias Gedde-Dahl and A. Hellmann and J. M. J. Janssen and Boris Labar and Alois H. Lang and Waleed Majeed and Georgi G Mihaylov and Jesper Stentoft and Leif Stenke and Josef Thaler and Noortje Thielen and Gregor E. G. Verhoef and Jaroslava Voglov{\'a} and Gert Jan Ossenkoppele and Andreas Hochhaus and Henrik Hjorth-Hansen and Satu Mustjoki and Sieghart Sopper and F. R. Giles and Kimmo V.K. Porkka and Dominik Georg Friedrich Wolf and Bj\orn Tore Gjertsen},
  booktitle={Haematologica},
  year={2017}
}
Monitoring of single cell signal transduction in leukemic cellular subsets has been proposed to provide deeper understanding of disease biology and prognosis, but has so far not been tested in a clinical trial of targeted therapy. We developed a complete mass cytometry analysis pipeline for characterization of intracellular signal transduction patterns in the major leukocyte subsets of chronic phase chronic myeloid leukemia. Changes in phosphorylated Bcr-Abl1 and the signaling pathways involved… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 3 times. VIEW TWEETS

Citations

Publications citing this paper.

References

Publications referenced by this paper.
Showing 1-10 of 36 references

Single-cell mass cytometry reveals intracellular survival/proliferative signaling in FLT3-ITD-mutated AML stem/progenitor cells.

Cytometry. Part A : the journal of the International Society for Analytical Cytology • 2015

Similar Papers

Loading similar papers…