Single-cell heterogeneity and cell-cycle-related viral gene bursts in the human leukaemia virus HTLV-1

@inproceedings{Billman2017SinglecellHA,
  title={Single-cell heterogeneity and cell-cycle-related viral gene bursts in the human leukaemia virus HTLV-1},
  author={Martin R Billman and David S Rueda and Charles R. M. Bangham},
  booktitle={Wellcome open research},
  year={2017}
}
Background: The human leukaemia virus HTLV-1 expresses essential accessory genes that manipulate the expression, splicing and transport of viral mRNAs.  Two of these genes, tax and hbz, also promote proliferation of the infected cell, and both genes are thought to contribute to oncogenesis in adult T-cell leukaemia/lymphoma.  The regulation of HTLV-1 proviral latency is not understood.  tax, on the proviral plus strand, is usually silent in freshly-isolated cells, whereas the minus-strand… CONTINUE READING
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A Language and Environment for Statistical Computing. R Foundation for Statistical Computing, Vienna

R R Core Team
Austria. R Foundation for Statistical Computing • 2017

The retrovirus HTLV-1 inserts an ectopic CTCF-binding site into the human genome.

Proceedings of the National Academy of Sciences of the United States of America • 2016

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