Single-cell genome sequencing: current state of the science

@article{Gawad2016SinglecellGS,
  title={Single-cell genome sequencing: current state of the science},
  author={Charles Gawad and Winston Koh and S. Quake},
  journal={Nature Reviews Genetics},
  year={2016},
  volume={17},
  pages={175-188}
}
  • Charles Gawad, Winston Koh, S. Quake
  • Published 2016
  • Biology, Medicine
  • Nature Reviews Genetics
  • The field of single-cell genomics is advancing rapidly and is generating many new insights into complex biological systems, ranging from the diversity of microbial ecosystems to the genomics of human cancer. In this Review, we provide an overview of the current state of the field of single-cell genome sequencing. First, we focus on the technical challenges of making measurements that start from a single molecule of DNA, and then explore how some of these recent methodological advancements have… CONTINUE READING

    Figures and Tables from this paper.

    Single-cell sequencing in stem cell biology
    • 73

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 124 REFERENCES
    Insights into the phylogeny and coding potential of microbial dark matter
    • 1,389
    • PDF
    Tumour evolution inferred by single-cell sequencing
    • 1,890
    • PDF