Single-cell gene profiling defines differential progenitor subclasses in mammalian neurogenesis.

@article{Kawaguchi2008SinglecellGP,
  title={Single-cell gene profiling defines differential progenitor subclasses in mammalian neurogenesis.},
  author={Ayano Kawaguchi and Tomoko Ikawa and Takeya Kasukawa and Hiroki R Ueda and Kazuki Kurimoto and Mitinori Saitou and Fumio Matsuzaki},
  journal={Development},
  year={2008},
  volume={135 18},
  pages={3113-24}
}
Cellular diversity of the brain is largely attributed to the spatial and temporal heterogeneity of progenitor cells. In mammalian cerebral development, it has been difficult to determine how heterogeneous the neural progenitor cells are, owing to dynamic changes in their nuclear position and gene expression. To address this issue, we systematically analyzed the cDNA profiles of a large number of single progenitor cells at the mid-embryonic stage in mouse. By cluster analysis and in situ… CONTINUE READING
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