Single-cell biological lasers

  title={Single-cell biological lasers},
  author={Malte C. Gather and Seok Hyun Yun},
  journal={Nature Photonics},
Scientists demonstrate living biological lasers by pumping cells containing green fluorescent protein in a highly reflective microcavity. The researchers also investigate the thresholds and modes of their cellular lasers. 
Biophotonics: Living lasers
Green fluorescent protein — an important biological imaging tool for many years — now forms the foundation of the first cellular laser.
Soft Matter and Biological Lasers
  • M. Humar
  • Biology
    OSA Advanced Photonics Congress (AP) 2019 (IPR, Networks, NOMA, SPPCom, PVLED)
  • 2019
Lasers were made from soft and biological materials. These lasers have been inserted into cells and tissues to perform a number of functions including tagging of cells, intracellular sensing,
Intracellular Semiconductor Nanodisk Lasers
We report the application of semiconductor nanodisk lasers within living cells. Our lasers have volumes 1000-fold smaller than eukaryotic nuclei, ultralow pulse energy lasing thresholds (Eth≈0.13pJ),
The cell laser
  • S. Yun
  • Physics, Education
    2015 Conference on Lasers and Electro-Optics (CLEO)
  • 2015
The first demonstration of a cell laser in 2011 opened new avenues for generating coherent light from living matters. Here we show progress in this new class of light sources and demonstrate their
Biophotonics: Cellular lasers
Turning living cells into miniature lasers offers new opportunities for cell labelling, tracking and sensing on a grand scale.
Lasing from living biological cells expressing green fluorescent protein
  • M. Gather, S. Yun
  • Biology
    2012 Conference on Lasers and Electro-Optics (CLEO)
  • 2012
We show that GFP, a biologically produced material, is a viable optical gain medium and construct true bio-lasers, in which the optical gain is provided by living mammalian or bacterial cells
Biologically inspired optofluidic lasers via chlorophylls
The first demonstration of chlorophyll lasers with two lasing bands was achieved by using an optofluidic ring-resonator. Our work revealed the mechanism and unique characteristics of chlorophyll
Distinguishing Small Molecules in Microcavity with Molecular Laser Polarization
A large number of lasers were designed to reflect changes of molecular concentration within the gas phase, but the properties of these lasers varied greatly in terms of their ability toDetect and identify biomolecules.
Oil droplets turn cells into tiny lasers
Injecting single cells with spheres of fluorescent dye could open new research and treatment avenues using light.
Deep Learning Powered Single Cell Biological Microlasers
Laser modes from single cell lasers were analyzed by deep learning analysis. The results demonstrated a prediction of cell sizes with subwavelength-level accuracy, showing the potential of laser mode


Nonlinear saturation and lasing characteristics of green fluorescent protein
Green fluorescent protein (GFP) has been of interest to researchers recently due to its use in nonlinear microscopy and biomedical applications. Through the use of nonlinear characterization, GFP has
Bright monomeric red fluorescent protein with an extended fluorescence lifetime
TagRFP is reported, a monomeric red fluorescent protein, which is characterized by high brightness, complete chromophore maturation, prolonged fluorescence lifetime and high pH-stability, which makes it an excellent tag for protein localization studies and fluorescence resonance energy transfer (FRET) applications.
Room-temperature sub-diffraction-limited plasmon laser by total internal reflection.
A room-temperature semiconductor sub-diffraction-limited laser is presented by adopting total internal reflection of surface plasmons to mitigate the radiation loss, while using hybrid semiconductor-insulator-metal nanosquares for strong confinement with low metal loss.
Fluorescence microscopy with diffraction resolution barrier broken by stimulated emission.
The diffraction barrier responsible for a finite focal spot size and limited resolution in far-field fluorescence microscopy has been fundamentally broken. This is accomplished by quenching excited
Video-Rate Far-Field Optical Nanoscopy Dissects Synaptic Vesicle Movement
This study demonstrates the emerging ability of optical microscopy to investigate intracellular physiological processes on the nanoscale in real time and map and describe the vesicle mobility within the highly confined space of synaptic boutons.
Handbook of Laser Wavelengths
Introduction Solid State Lasers Crystalline Paramagnetic Ion Lasers Glass Lasers Solid State Dye Lasers Color Center Lasers Semiconductor Lasers Polymer Lasers Liquid Lasers Organic Dye Lasers Rare
Principles of Lasers
Introductory Concepts.- Interaction of Radiation with Atoms and Ions.- Energy Levels, Radiative, and Nonradiative Transitions in Molecules and Semiconductors.- Ray and Wave Propagation Through
Demonstration of a spaser-based nanolaser
It is shown that 44-nm-diameter nanoparticles with a gold core and dye-doped silica shell allow us to completely overcome the loss of localized surface plasmons by gain and realize a spaser, and that outcoupling of surface plasmon oscillations to photonic modes at a wavelength of 531 nm makes this system the smallest nanolaser reported to date—and to the authors' knowledge the first operating at visible wavelengths.
Stimulated Optical Radiation in Ruby
Schawlow and Townes1 have proposed a technique for the generation of very monochromatic radiation in the infra-red optical region of the spectrum using an alkali vapour as the active medium. Javan2