Single-cell analysis reveals that insulation maintains signaling specificity between two yeast MAPK pathways with common components.

@article{Patterson2010SinglecellAR,
  title={Single-cell analysis reveals that insulation maintains signaling specificity between two yeast MAPK pathways with common components.},
  author={Jesse C Patterson and Evguenia S Klimenko and J. Thorner},
  journal={Science signaling},
  year={2010},
  volume={3 144},
  pages={ra75}
}
Eukaryotic cells use multiple mitogen-activated protein kinase (MAPK) cascades to evoke appropriate responses to external stimuli. In Saccharomyces cerevisiae, the MAPK Fus3 is activated by pheromone-binding heterotrimeric guanosine triphosphate-binding protein (G protein)-coupled receptors to promote mating, whereas the MAPK Hog1 is activated by hyperosmotic stress to elicit the high-osmolarity glycerol (HOG) response. Although these MAPK pathways share several upstream components, exposure to… CONTINUE READING

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