Single-cell analysis reveals a stem-cell program in human metastatic breast cancer cells

@article{Lawson2015SinglecellAR,
  title={Single-cell analysis reveals a stem-cell program in human metastatic breast cancer cells},
  author={Devon A Lawson and Nirav R Bhakta and Kai Kessenbrock and Karin Dorien Prummel and Ying Di Yu and Ken Takai and Alicia Zhou and Henok Eyob and Sanjeev Balakrishnan and Chih-Yang Wang and Paul Yaswen and Andrei Goga and Zena Werb},
  journal={Nature},
  year={2015},
  volume={526},
  pages={131-135}
}
Despite major advances in understanding the molecular and genetic basis of cancer, metastasis remains the cause of >90% of cancer-related mortality. Understanding metastasis initiation and progression is critical to developing new therapeutic strategies to treat and prevent metastatic disease. Prevailing theories hypothesize that metastases are seeded by rare tumour cells with unique properties, which may function like stem cells in their ability to initiate and propagate metastatic tumours… CONTINUE READING
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