Single-cell analysis of ribonucleotide reductase transcriptional and translational response to DNA damage.

@article{Mazumder2013SinglecellAO,
  title={Single-cell analysis of ribonucleotide reductase transcriptional and translational response to DNA damage.},
  author={Aprotim Mazumder and Katja Tummler and Mark Bathe and Leona D. Samson},
  journal={Molecular and cellular biology},
  year={2013},
  volume={33 3},
  pages={635-42}
}
The ribonucleotide reductase (RNR) enzyme catalyzes an essential step in the production of deoxyribonucleotide triphosphates (dNTPs) in cells. Bulk biochemical measurements in synchronized Saccharomyces cerevisiae cells suggest that RNR mRNA production is maximal in late G(1) and S phases; however, damaged DNA induces RNR transcription throughout the cell… CONTINUE READING