Single-cell analysis of regulatory gene expression in quiescent and activated mouse skeletal muscle satellite cells.

@article{Cornelison1997SinglecellAO,
  title={Single-cell analysis of regulatory gene expression in quiescent and activated mouse skeletal muscle satellite cells.},
  author={D. D. W. Cornelison and Barbara J. Wold},
  journal={Developmental biology},
  year={1997},
  volume={191 2},
  pages={
          270-83
        }
}
Repair and regeneration of adult skeletal muscle are mediated by satellite cells. In healthy muscle these rare mononucleate muscle precursor cells are mitotically quiescent. Upon muscle injury or degeneration, members of this self-renewing pool are activated to proliferate and then differentiate. Here we analyzed in single satellite cells the expression of a set of regulatory genes that are candidates for causal roles in satellite cell activation, maturation, and differentiation. Individual… CONTINUE READING

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