Single-cell analysis of normal and FOXP3-mutant human T cells: FOXP3 expression without regulatory T cell development.

@article{Gavin2006SinglecellAO,
  title={Single-cell analysis of normal and FOXP3-mutant human T cells: FOXP3 expression without regulatory T cell development.},
  author={Marc A. Gavin and Troy R. Torgerson and Evan G. Houston and Paul deRoos and William Yew-Wai Ho and Asbj{\o}rg Stray-Pedersen and Elizabeth L. Ocheltree and Philip D. Greenberg and Hans D. Ochs and Alexander Yu Rudensky},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2006},
  volume={103 17},
  pages={
          6659-64
        }
}
Forkhead winged-helix transcription factor Foxp3 serves as the dedicated mediator of the genetic program governing CD25+CD4+ regulatory T cell (T(R)) development and function in mice. In humans, its role in mediating T(R) development has been controversial. Furthermore, the fate of T(R) precursors in FOXP3 deficiency has yet to be described. Making use of flow cytometric detection of human FOXP3, we have addressed the relationship between FOXP3 expression and human T(R) development. Unlike… CONTINUE READING
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