Single-cell analysis of CD4+ T-cell differentiation reveals three major cell states and progressive acceleration of proliferation

@inproceedings{Proserpio2016SinglecellAO,
  title={Single-cell analysis of CD4+ T-cell differentiation reveals three major cell states and progressive acceleration of proliferation},
  author={Valentina Proserpio and Andrea Piccolo and Liora Haim-Vilmovsky and Gozde Kar and Tapio L{\"o}nnberg and Valentine Svensson and Jhuma Pramanik and Kedar Nath Natarajan and Weichao Zhai and Xiuwei Zhang and Giacomo Donati and Melis Kayikci and Jurij Kotar and Andrew N J McKenzie and Ruddy Montandon and Oliver Billker and Steven Woodhouse and Pietro Cicuta and Mario Nicodemi and Sarah A Teichmann},
  booktitle={Genome biology},
  year={2016}
}
BackgroundDifferentiation of lymphocytes is frequently accompanied by cell cycle changes, interplay that is of central importance for immunity but is still incompletely understood. Here, we interrogate and quantitatively model how proliferation is linked to differentiation in CD4+ T cells.ResultsWe perform ex vivo single-cell RNA-sequencing of CD4+ T cells during a mouse model of infection that elicits a type 2 immune response and infer that the differentiated, cytokine-producing cells cycle… CONTINUE READING

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