Single-cell Raman and fluorescence microscopy reveal the association of lipid bodies with phagosomes in leukocytes.

@article{Manen2005SinglecellRA,
  title={Single-cell Raman and fluorescence microscopy reveal the association of lipid bodies with phagosomes in leukocytes.},
  author={Henk-Jan van Manen and Yvonne M Kraan and Dirk Roos and Cees Otto},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2005},
  volume={102 29},
  pages={
          10159-64
        }
}
Cellular imaging techniques based on vibrational spectroscopy have become powerful tools in cell biology because the molecular composition of subcellular compartments can be visualized without the need for labeling. Using high-resolution, nonresonant confocal Raman microscopy on individual cells, we demonstrate here that lipid bodies (LBs) rich in arachidonate as revealed by their Raman spectra associate with latex bead-containing phagosomes in neutrophilic granulocytes. This finding was… CONTINUE READING
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