Single-cell RNAseq reveals cell adhesion molecule profiles in electrophysiologically defined neurons.

@article{Fldy2016SinglecellRR,
  title={Single-cell RNAseq reveals cell adhesion molecule profiles in electrophysiologically defined neurons.},
  author={Csaba F{\"o}ldy and Spyros Darmanis and Jason N Aoto and Robert C Malenka and Stephen R Quake and Thomas C S{\"u}dhof},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2016},
  volume={113 35},
  pages={E5222-31}
}
In brain, signaling mediated by cell adhesion molecules defines the identity and functional properties of synapses. The specificity of presynaptic and postsynaptic interactions that is presumably mediated by cell adhesion molecules suggests that there exists a logic that could explain neuronal connectivity at the molecular level. Despite its importance, however, the nature of such logic is poorly understood, and even basic parameters, such as the number, identity, and single-cell expression… CONTINUE READING
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