Single-cell RNA-seq technology lends a hand into HSC ontogeny

Hematopoietic stem cells (HSCs) are rare populations in the bone marrow of adult mammals which produce millions of blood cells for daily circulation by balancing self-renewal and multi-lineage differentiation. In vertebrates, a subset of specialized mesodermal precursor cells commit to hemato-poietic cells after gastrulation, which are separated into two… (More)