Single-cell RNA-seq supports a developmental hierarchy in human oligodendroglioma

  title={Single-cell RNA-seq supports a developmental hierarchy in human oligodendroglioma},
  author={Itay Tirosh and Andrew S Venteicher and Christine H Hebert and Leah E. Escalante and Anoop P Patel and Keren Yizhak and Jonathan M. Fisher and Christopher Rodman and Christopher W. Mount and Mariella G Filbin and Cyril Neftel and Niyati T Desai and Jackson Nyman and Benjamin Izar and Christina C Luo and Joshua M. Francis and Aanand A. Patel and Maristela Lika Onozato and Nicol{\`o} Riggi and Kenneth J Livak and Dave Gennert and Rahul Satija and Brian Vala Nahed and William Thomas Curry and Robert L. Martuza and Ravindra Mylvaganam and Anthony John Iafrate and Matthew P. Frosch and Todd R. Golub and Miguel N. Rivera and Gad Getz and Orit Rozenblatt-Rosen and Daniel P Cahill and Michelle Monje and Bradley E. Bernstein and David N Louis and Aviv Regev and Mario L Suv{\`a}},
Although human tumours are shaped by the genetic evolution of cancer cells, evidence also suggests that they display hierarchies related to developmental pathways and epigenetic programs in which cancer stem cells (CSCs) can drive tumour growth and give rise to differentiated progeny. Yet, unbiased evidence for CSCs in solid human malignancies remains elusive. Here we profile 4,347 single cells from six IDH1 or IDH2 mutant human oligodendrogliomas by RNA sequencing (RNA-seq) and reconstruct… CONTINUE READING
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