Single cardiac sarcoplasmic reticulum Ca2+-release channel: activation by caffeine.

@article{Rousseau1989SingleCS,
  title={Single cardiac sarcoplasmic reticulum Ca2+-release channel: activation by caffeine.},
  author={Eric Rousseau and Gerhard Meissner},
  journal={The American journal of physiology},
  year={1989},
  volume={256 2 Pt 2},
  pages={H328-33}
}
Caffeine is thought to affect excitation-contraction coupling in cardiac muscle by activating the sarcoplasmic reticulum (SR) Ca2+-release channel. The effect of caffeine at the single channel level was studied by incorporating canine cardiac SR vesicles into planar lipid bilayers. Cardiac Ca2+-release channels were activated in a steady-state manner by millimolar cis-caffeine and displayed a unitary conductance (77 pS in 50 mM Ca2+ trans) similar to that previously observed for the Ca2… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 112 extracted citations

Similar Papers

Loading similar papers…