Single bolus of midazolam versus bolus midazolam plus meperidine for colonoscopy: a prospective, randomized, double-blind trial.

@article{Radaelli2003SingleBO,
  title={Single bolus of midazolam versus bolus midazolam plus meperidine for colonoscopy: a prospective, randomized, double-blind trial.},
  author={Franco Radaelli and Gianmichele Meucci and Vittorio Terruzzi and Giancarlo Spinzi and Gianni Imperiali and Enrico Strocchi and Nicoletta Lenoci and Natalia L Terreni and Giovanna Mandelli and Giorgio Minoli},
  journal={Gastrointestinal endoscopy},
  year={2003},
  volume={57 3},
  pages={329-35}
}
BACKGROUND The aim of this study was to determine whether a single bolus of meperidine in addition to midazolam improves patient tolerance during colonoscopy. METHODS Consecutive patients undergoing outpatient colonoscopy were randomly assigned in double-blind fashion to receive a single rapid intravenous bolus of 5 mg of midazolam and placebo (Group A, n = 125) or 5 mg midazolam plus 50 mg meperidine (Group B, n = 128). Tolerance (4-point scale: 1 excellent, 4 unbearable), pain (4-point… CONTINUE READING

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