Single-blinded controlled trial of low-dose oral IFN-alpha for the treatment of xerostomia in patients with Sjögren's syndrome.

@article{Shiozawa1998SingleblindedCT,
  title={Single-blinded controlled trial of low-dose oral IFN-alpha for the treatment of xerostomia in patients with Sj{\"o}gren's syndrome.},
  author={Shunichi Shiozawa and Yoko Tanaka and Kazuko Shiozawa},
  journal={Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research},
  year={1998},
  volume={18 4},
  pages={255-62}
}
A single-blinded controlled trial was conducted to test the efficacy of low-dose oral human interferon-alpha (IFN-alpha) to improve salivary function in patients with Sjögren's syndrome. Fifty-six outpatients with primary and 4 patients with secondary Sjögren's syndrome were assigned randomly into treatment groups of either IFN-alpha or sucralfate (control). The IFN-alpha (150 IU) or sucralfate (250 mg) was given orally three times a day for 6 months. Saliva was quantitated monthly by the Saxon… CONTINUE READING

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