Single-beat estimation of end-diastolic pressure-volume relationship: a novel method with potential for noninvasive application.

  title={Single-beat estimation of end-diastolic pressure-volume relationship: a novel method with potential for noninvasive application.},
  author={Stefan Klotz and Ilan Hay and Marc L. Dickstein and Geng-hua Yi and Jie Wang and Mathew S. Maurer and David A. Kass and Daniel Burkhoff},
  journal={American journal of physiology. Heart and circulatory physiology},
  volume={291 1},
  • S. KlotzIlan Hay D. Burkhoff
  • Published 1 July 2006
  • Medicine
  • American journal of physiology. Heart and circulatory physiology
Whereas end-systolic and end-diastolic pressure-volume relations (ESPVR, EDPVR) characterize left ventricular (LV) pump properties, clinical utility of these relations has been hampered by the need for invasive measurements over a range of pressure and volumes. We propose a single-beat approach to estimate the whole EDPVR from one measured volume-pressure (Vm and Pm) point. Ex vivo EDPVRs were measured from 80 human hearts of different etiologies (normal, congestive heart failure, left… 

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