Single-arm study of bridging therapy with low-molecular-weight heparin for patients at risk of arterial embolism who require temporary interruption of warfarin.

@article{Kovacs2004SinglearmSO,
  title={Single-arm study of bridging therapy with low-molecular-weight heparin for patients at risk of arterial embolism who require temporary interruption of warfarin.},
  author={Michael J. Kovacs and Clive Kearon and Marnie Rodger and David R Anderson and Alexander G. G. Turpie and Shannon M. Bates and Louis Desjardins and James Demetrios Douketis and Susan R. Kahn and Susan Solymoss and Philip S Wells},
  journal={Circulation},
  year={2004},
  volume={110 12},
  pages={
          1658-63
        }
}
BACKGROUND When warfarin is interrupted for surgery, low-molecular-weight heparin is often used as bridging therapy. However, this practice has never been evaluated in a large prospective study. This study was designed to assess the efficacy and safety of bridging therapy with low-molecular-weight heparin initiated out of hospital. METHODS AND RESULTS This was a prospective, multicenter, single-arm cohort study of patients at high risk of arterial embolism (prosthetic valves and atrial… CONTINUE READING
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