Single- and repeated-dose oral toxicity studies of citicoline free-base (choline cytidine 5'-pyrophosphate) in Sprague-Dawley rats.

@article{Schauss2009SingleAR,
  title={Single- and repeated-dose oral toxicity studies of citicoline free-base (choline cytidine 5'-pyrophosphate) in Sprague-Dawley rats.},
  author={Alexander G. Schauss and Susan Somfai-Relle and Istvan Financsek and R{\'o}bert Gl{\'a}vits and Stefan Parent and John R Endres and Tibor Varga and Zs Sz{\"u}cs and Amy Clewell},
  journal={International journal of toxicology},
  year={2009},
  volume={28 6},
  pages={479-87}
}
The dietary supplement Citicoline free-base (choline cytidine 5'-pyrophosphate) was toxicologically evaluated in Sprague-Dawley rats using oral gavage. In an acute 14-day study, 2000 mg/kg was well tolerated. In a 90-day study, 100, 350, and 1000 mg/kg/day doses resulted in no mortality. In males, slight significant increases in serum creatinine (350 and 1000 mg/kg/day), and decreases in urine volume (all treated groups) were observed. In females, slight significant increases in total white… CONTINUE READING
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